It is time - time to change to HTML5, CSS3 and all the goodness which that brings.
By means of html5 shiv - or other js - we can emulate html5 and css3 features in lesser browsers, so there’s no reason to not use it today.
The HTML5 Boilerplate starting point is extremely popular.
Responsive webdesign is the new black these days - design once and your web app can run on phones, tablets, whatever.
IMO, the most promising project is Skeleton.
It is based on HTML5 boilerplate - it’s the project of a boilerplate team member - and combines the boilerplate with a responsive grid (based on 960gs).
I guess you’ve heard of the Twitter Bootstrap framework.
One of the authors is the boss of the author of Skeleton, so it sort of comes from Twitter as well.
The difference is that Bootstrap is not responsive and it’s already styled.
Skeleton, on the other hand, is lightly styled and a good starting point for responsive sites.
BluePrint is good, but the times have changed - not even the BluePrint author uses it now.
Check out Skeleton here:
And this topic - for reference:
Then come back and vote for it.
If you like the looks of Bootstrap, know that it’s fairly easy to combine it with Skeleton.
I did evaluate a whole lot of options - and settled on Skeleton because it’s not intrusive and because it’s responsive.
1140 grid is also nice, but it doesn’t play well with html5 boilerplate unfortunately.
If it did, it would have been my choice number one.
Less CSS framework is awesome, but probably a bit too heavy to ship with Yii generated apps by default.
Compass - same as Less.
Skeleton is made by a guy which is a team member of the boilerplate project, and an employee of one of the Twitter Bootstrap maintainers.
It has gotten a lot of positive press, even if it’s brand new.
Responsive design is the new black.
Get used to it.